Lead (Pb) is a highly toxic pollutant that can damage neurological, cardiovascular, immunological, developmental, and other major organ systems (U.S. EPA, 2013). This project aims to create a rigorous approach to quantify adult health benefits from a reduction in Pb exposure for cardiovascular disease mortality, which would strengthen EPA’s regulatory analyses and more completely characterize the effects of its programs. The purpose of this report is to present a concentration response function to estimate the number of cardiovascular disease deaths which would be avoided as a result of a decrease in Pb exposure.